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If nasal delivery achieves effective central appetite suppression at lower total systemic doses than injection, the cost per therapeutic outcome could potentially favor the nasal route despite lower bioavailability

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The ideal candidate for B12 injections include those who are deficient in B12, at risk of being deficient in B12, or those with signs of fatigue, weakness, or cognitive deficits

doi:10.1111/j.1753-4887.2009.00246.x

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ARA 290 appears to be safe in patients with sarcoidosis and can reduce neuropathic symptoms