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Therefore, additional polar interactions with sulfated ligand-mediated by R197 ECL2 significantly enhance the affinity and potency, providing an explanation for the observation that CCK1R prefers sulfated CCK while CCK2R binds to the sulfated and non-sulfated ligands equally well
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The move, environmentalists say, could compromise habitat for some of the states threatened and endangered species, in addition to dewatering what some consider one of the wildest sections left of the Rio Grande
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