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LepR is expressed in hypothalamic astrocytes [192, 193], and hypothalamic astrocytes participate in the mediation of leptin signaling [194, 195]

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UK Chief Medical Officers' guidelines recommend: Strength activities on at least 2 days per week, targeting major muscle groups to stimulate muscle protein synthesis and preserve lean tissue Cardiovascular activity for at least 150 minutes weekly of moderate-intensity exercise (or 75 minutes of vigorous activity) Daily movement and reducing sedentary behaviour to support overall energy expenditure Adequate protein intake is important for muscle preservation

The role of GLP-1 receptor agonists in the management of type 2 diabetes has been established, with compelling evidence showing marked cardiovascular benefits associated with treatment

Recent cardiovascular outcomes trials have shifted how clinicians think about therapy selection, Read More GLP-1 Resistance in Diabetes Care: Should Poor Response Change Treatment Strategy

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