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Bone metastasis is a major concern in patients with CRPC

Potassium sparing diuretics: the addition of potassium-sparing diuretics (i.e., mineralocorticoid receptor antagonists or ENaC inhibitors like amiloride or triamterene) may be especially helpful for hypokalemia caused by loop +/- thiazide diuretics

At 30 mg/mL, which is a rare but available concentration, 50 units delivers the maximum FDA-studied dose of 15 mg

This is true for both diabetic and non diabetic patients, which is why Wegovy has been FDA approved for weight loss since 2021

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