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Description
Unlike tirzepatide, which targets two receptors (GIP + GLP-1), retatrutide activates three: GIP, GLP-1, and glucagon receptors

However, long-acting GLP-1s, like victoza, trulicity and ozempic, are sometimes prescribed off-label in clinical practice for individuals with T1D

These may include depression, anxiety, and a reduced ability to experience pleasure

In individuals with diabetes, it helps the pancreas regulate the amount of insulin in the body

An open research question is whether GLP-1s, independent of any formal mindfulness practice, produce cognitive effects that resemble components of mindful eating

Data source: the KFF Health Tracking Poll, fielded October 27 to November 2, 2025 among 1,350 U.S
