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Common side effects reported with retatrutide include: Nausea, vomiting, and diarrhoea (most frequent, particularly during dose escalation) Decreased appetite Constipation Injection site reactions Mild increases in heart rate Cagrilintide has demonstrated a generally well-tolerated profile, with gastrointestinal symptoms also being the most commonly reported adverse effects

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Gastrointestinal side effects observed under cotadutide effects are similar in quality but more severe than those under GLP-1RA treatment (52)

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Non-pharmacological approaches including rest, cold compresses applied to the forehead or neck, relaxation techniques, and stress management may provide additional relief

Healthcare resource utilization was also compared between groups
