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Lancet 2: 2021, 1964

JAMA 326 , 20212030 (2021)

7.1 PYYs effect on bone metabolism in vivo Evidence from rodent studies supports that PYY regulates bone homeostasis by modulating osteoclast and osteoblast activity

Some of the most common GI side effects include: Nausea Bloating Reflux Diarrhea Abdominal pain Constipation Other side effects (including anecdotal reports and those noted in clinical studies) include gallstones/biliary disease (which is associated with speedy weight loss due to other causes as well), gastroparesis, and pancreatitis, among others

Methylcobalamin is an active, highly bioavailable form of B12 that supports energy metabolism and nerve function, both of which can be affected during periods of significant dietary change

View source TRIUMPH-4 Phase 3 topline results Eli Lilly Company press release summarizing Phase 3 retatrutide results in obesity and knee osteoarthritis