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Abbreviations AE Adverse event BMI Body mass index BP Blood pressure CI Confidence interval CV Cardiovascular CVOT Cardiovascular outcome trial DBP Diastolic blood pressure ETD Estimated treatment difference GIP Glucose-dependent insulinotropic polypeptide GLP-1 RA Glucagon-like peptide-1 receptor agonist HbA1c Glycated haemoglobin A1c MACE-4 Major adverse cardiovascular events proAND Pro-atrial natriuretic peptide SBP Systolic blood pressure T2D Type 2 diabetes WL-D Weight-loss dependent WL-IND Weight-loss independent Author contributions HP contributed to the conception of the work

Allerdings hat diese Patientin eine klare Indikation fr eine bariatrische Operation, fr die sie sich aufgrund der ausgeprgten Adipositas und der langjhrigen Gewichtsreduktionsversuche qualifiziert (8, 9)

59 GPIb-IX-V GPIb-IX-V complex, a leucine-rich glycoprotein family receptor, is involved in cell signaling, adhesion, growth and development
But it also exposes a deeper truth: even with every biomarker and algorithm, human metabolism resists simplicity