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The doses used were standard doses

It should be avoided or used only under clinician supervision in patients with kidney disease, older adults, or those at risk for electrolyte abnormalities , due to the risk of hypermagnesemia., Use sparingly: Stimulant laxatives (such as bisacodyl or senna) may be effective for intermittent rescue use , but they can cause cramping and are generally not needed for routine long-term management when osmotic agents are effective., Safety note: Regular stimulant laxative use that causes frequent loose stools may contribute to dehydration and electrolyte imbalance (including hypokalemia) and should therefore be intermittent unless clinician-directed . What about docusate (Colace)

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Acetylcholine acts on M3 muscarinic receptors expressed on endothelial cells, activating endothelial nitric oxide synthase (eNOS) and promoting NO production [20,21]

February 2026 Updates: Consolidated Appropriations Act Section 204 Reporting Mandate: Prescription Drug Spending Whats Required: CAA Section 204 requires health plans and insurers to report prescription drug and health care spending data (RxDC) to federal agencies