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75,536 Alternative splicing affects genes (such as FGFR , ERG , VEGFA , and AR ) that are clearly linked to the etiology of PCa, allowing us to develop novel targeted therapies that modulate alternative splicing for the treatment of PCa

Metformin may modestly help preserve lean mass through its effects on AMPK activation in muscle tissue, though the evidence for this is preliminary

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12-Month Treatment Comparison Without insurance or assistance programs: Ozempic: $11,628 ($969 12 months) Compounded semaglutide: $2,388 ($199 12 months) Savings with compounded: $9,240 With insurance and Ozempic savings card (best-case scenario of $25/month copay): Ozempic: $300 ($25 12 months) Compounded semaglutide: $2,388 ($199 12 months) In the best-case scenario with excellent insurance coverage and qualification for maximum savings card benefits, brand-name Ozempic is cheaper

2c , Supplementary Fig