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Insulin resistance and chronic hyperglycemia cause a cascade of pathological events in the brain, including neuroinflammation, impaired neurotransmitter systems and energy metabolism, oxidative stress, and vascular pathologies that ultimately lead to neurodegeneration, loss of synaptic plasticity, brain aging, cognitive impairment, and dementia

Pharmacology & Therapeutics, 155, 49-59

if Orforglipron is successfully commercialized, Chugai will also be entitled to royalties for patent usage.

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