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The oxidative milleu enhances ECM stability and stiffness through the upregulation of enzymes like lysyl oxidases (LOX and LOXL2), which catalyzes the crosslinking of collagen and elastin fibers, increasing EMC tensile strength (127, 128)

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(2003) Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program

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Treatment with m6A inhibitor (STM2457) remarkably targeted PSAT1, PSPH and PHGDH, which significantly enhanced the sensitivity of HCC cells to sorafenib and Lenvatinib, suggesting that STM2457 treatment could represent a promising therapeutic strategy for HCC [143]