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Mechanism of toxicity After application of a spot-on emulsion, the lipophilic pyrethroids are quickly absorbed through the skin into the systemic circulation

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Southeast Asian J Trop Med Public Health 34(1):3742 Tripi S, Di Gaetano G, Soresi M, Carroccio A, Bonfissuto G, Savi A, Vuturo O, Montalto G (1998) Acetylcysteine therapy for chronic hepatitis C: are its effects synergistic with interferon alpha

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This cascade results in transcription of inflammatory genes, including those encoding TNF-, IL-1, IL-6, IL-12p40, and cyclooxygenase 24

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J Am Chem Soc 134: 1201612027

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