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While tirzepatide does not directly affect B12 absorption like metformin, reduced intake of animal productscommon during appetite suppressionmay lead to inadequate B12 levels

Intramuscular administration allows B12 to bypass hepatic metabolism and enter systemic circulation directly, which is why this route differs from oral supplementation

Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory