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In addition to enzymatic degradation, chemical methods have been used both to modify the structure of mucus for drug delivery and to treat mucus overproduction

Hesseltine C

We confirm that C-PC selectively targets GBM cells by enhancing cellular uptake in resistant phenotypes while sparing normal cells, and that C-PC-CDDP combination therapy enhances cytotoxicity significantly in treatment-sensitive U87 cells through apoptosis induction and ROS modulation, the latter involving upregulated MnSOD and catalase expression, and C-PC monotherapy offers superior efficacy compared to combination treatment in CDDP-resistant U87-EGFRvIII cells

doi: 10.1002/jpln.200900260 216 ZhangJ.ZhouH.LiH.YingZ.LiuX

Glutathione catalyses two important chemical reactions to remove free radicals from the body: glutathione S-transferases (GST) and glutathione peroxidases (GPx)

As such, it is apparent that additional experimentation focusing on genomics, environmental/nutritional components and their crosstalk is warranted to determine the causal factor(s) that reduce both cystine and selenoprotein levels in children affected with konzo to unravel the biological mechanism behind this disease