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The initiation of a productive HCV infection involves several cellular factors that trigger virus uptake via tight junctions, and three of the major molecules mediating HCV cell entry, the scavenger receptor (SR-BI), the LDL-receptor (LDL-R) and heparan sulfate proteoglycans (HSPG) also interact with lipoproteins or lipids

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doi: 10.1186/1744-9081-2-1

Side effects also increase with dose, primarily gastrointestinal symptoms like nausea, vomiting, and diarrhea