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Description
This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)

10.3390/plants10102123 [DOI] [PMC free article] [PubMed] [Google Scholar] Golmwen S

Popichak KA, Hammond SL, Moreno JA et al (2018) Compensatory expression of Nur77 and Nurr1 regulates NF-B-dependent inflammatory signaling in astrocytes

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Dafr gibt es mehrere Grnde

mitochondrial dysfunction
