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While this has garnered substantial information on where active canonical Wnt signaling is required during development and regeneration, much of the identity of Wnt secreting cells and what combinations of Wnt and Frizzled members are responsible for activating Wnt/-catenin signaling in specific developmental and regenerative processes still remain unknown (Figure 2)

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The integration of Vitamin D absorption and VDR signaling provides a mechanistic link to aging-associated outcomes

It belongs to a wider set of peptides moving through longevity and biohacker circles, including BPC-157, Cerebrolysin, Semax, Selank, Dihexa, P21, and the neurotrophic factors BDNF and klotho, whose human cognitive evidence ranges from thin to absent and which I reviewed in detail here
