cannabis and glutathione Behavioral biochemical effects of Sativa and their modulation by antidepressant drugs Cannabis sativa L. Bioactive Compounds

-glutamate-cysteinyl-synthetase or GCL is in part regulated by glutathione feedback inhibition,[26] which can be partially prevented by an excess of glutamic acid that blocks the regulatory site on the enzyme.[25] Thus, if glutathione is exhausted due to OS, exposure to xenobiotics or inflammation, de novo synthesis of glutathione is up-regulated.[26] Inhibition of GS results in the accumulation of -L-glutamyl-L-cysteine that is converted to cysteine and oxoproline by GCT, and then oxoproline is converted to glutamic acid via 5-oxoprolinase reaction by oxoproplinase

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Glutathione synthesis and turnover in the human erythrocyte

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The Compensatory Immune-Regulatory Reflex System (CIRS) in Depression and Bipolar Disorder

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