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Insulin-regulated hepatic gluconeogenesis through FOXO1PGC-1 interaction

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10.1038/s41419-018-0687-6 12 CastaoC.KalkoS.NovialsA.PrrizasM

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We find that in response to starvation, the sirtuin 1 ortholog SIR-2.1 activates lipolysis by upregulation of the adipose triglyceride lipase ATGL-1

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Lysosomal degradation of newly formed insulin granules contributes to cell failure in diabetes

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