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Methods 337 , 715 (2008)

It has been suggested that the Keap1 protein may contain critical cysteine residues, which upon oxidation alter the conformation of the protein releasing any associated protein such as Nrf2 [24]

The main roles for PGEs and PGI 2 in inflammation may in fact be in the generation of hyperalgesia, sensitization of the tissue to the irritant and pain producing activity of the amine and peptide type of mediators of inflammation (Ferreira and Nakamura, 1979

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In addition to exhibiting selectivity and saturability, active transport requires the expenditure of energy and may be blocked by inhibitors of cellular metabolism

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