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Excess bioaccumulation of MPs induces increased germ cell apoptosis and disrupted spermatogenesis by causing abscission and irregular arrangement of spermatogenic cells (72) and sperm DNA fragmentation

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De novo synthesis of glutathione is required for both entry into and progression through the cell cycle

Nature 529 , 226230 (2016)

In this cells, the apoptotic pathway relied upon the same Trx1/p38MAPK/p53 signaling axis and cell survival to diamide relied upon redox activation of NE2FL2, in a way independent of Keap1 oxidation, but responsive to ERK1/2 activation (Filomeni et al., 2012)

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