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Data availability For inferring the maximum entropy-based fitness landscape model, NS3 subtype 1a aligned sequences (coverage 99%) were downloaded from the publicly available HCV GLUE sequence database, For validation of the inferred NS3 1a fitness landscape model, the ex-vivo experimental fitness (infectivity) measurements were compiled from five literature reports 9,10,21,28,29

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Treatment with ALCAR after HI decreased the significant increase in protein carbonyl formation that was found only in the brain of male pups in both hemispheres of the cerebral cortex, hippocampus and perirhinal cortex [38]