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All structural data were analyzed and figures were generated using PyMOL (version 3.0)

Safety, tolerability, PK, and PD in people with overweight/obesity

The regulatory and basal phosphorylation sites of hormone-sensitive lipase are dephosphorylated by protein phosphatase-1, 2A and 2C but not by protein phosphatase-2B

There is some debate as to whether it is homocysteine itself that causes these problems or the underlying factors that have led to elevated homocysteine levels

If the Ellman test is positive (yellow), the ring reaction is incomplete

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