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These short-lived molecules can be effluxed, and bind and activate specific receptors on neighboring cells to exert their biological effect such as pain and inflammation

Br J Cancer 110 , 183188 (2014)

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Moreover, an in vitro study demonstrated that human CRP directly contributes to adaptive immunity, with its native form specifically binding to human Jurkat T cells and to mouse naive CD4 + T cells, modulating their Th1 and Th2 responses and thus alleviating experimental autoimmune encephalomyelitis [116]

Nasal administration has slightly lower bioavailability than injection (~60-70% vs 80-90%) but is far more convenient and still highly effective for erectile function and libido enhancement