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2015 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension

Mechanistically, HHcy promoted the activation of B cells, which secreted anti-beta 2 glycoprotein I (2GPI) antibodies that target GECs to increase the number of oxidized phospholipids, thus facilitating lipid peroxidation by activating PE synthases ethanolamine kinase 2 (ETNK2) and ethanolamine-phosphatecytidylyltransferase 2 (PCYT2) [262]

[DOI] [PubMed] [Google Scholar] 150.Safarpour S., Pirzadeh M., Ebrahimpour A., Shirafkan F., Madani F., Hosseini M., Moghadamnia A.A., Kazemi S

For example, Nrf2 is required in fibroblast,168 but not in liver.159 These metabolic enzymes and carriers are also involved in the hepatic handling of electrophilic species that alkylate nucleophilic sites on peptides, proteins and nucleic acids, forming covalent adducts that can significantly compromise cellular integrity and function