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In the future, considerable effort will be needed to characterize the interactions of these epigenetic marks with metabolic reprogramming factors in cancer cells
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FIGURE 8 3.8 Immunohistochemical findings The immunohistochemical investigation demonstrated a significant increase in expression of proapoptotic makers, Bax, and caspase-3, in MTX treated group, which was associated with decreased antiapoptotic marker, Bcl-2, expression when compared to the CTRL group (Figure 9)

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doi: 10.1016/j.toxlet.2012.06.003 115
EPO might also interact with TPR but may not be a suitable candidate for further research in this area due to its ancillary cardiovascular and hematopoietic action
