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Three chamber sociability The Three Chamber test was conducted to measure the sociability of mice when allowed to interact with a novel mouse or a similarly sized inanimate object

However, educated by environmental signals in the TME, macrophages can acquire a M2-like phenotype and transform into tumor-associated macrophages (TAMs), which are known to facilitate tumor progression 18,19,20

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Acknowledgments The authors thank Arnulf Koeppen for generously providing the FRDA heart pictures, Dr

Oncotarget 7 , 2758427598 (2016)

The accumulation of lactate in the TME can be reduced through increasing its uptake and utilization by tumor cells, thus reducing its influence on tumor cells and immune cells, or through finding effective targets to cause tumors to undergo aerobic metabolism instead of the Warburg effect, thereby inhibiting tumor invasion