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doi: 10.1074/jbc.R117.789271

Pentoxifylline has been proven to significantly reduce liver lipid accumulation, lower blood lipid levels, and improve insulin resistance, thereby treating non-alcoholic fatty liver disease [79]

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Compared to wild-type cells, IRE1-null cells have significantly elevated GSH levels, indicating that the resistance to ferroptosis correlates with altered GSH metabolism in IRE1-deficient cells (Fig