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Adipose tissue samples were obtained from the tail base region of adult healthy and EMS-affected horses under local anesthesia with 2% lidocaine (Polfa S.A., Warsaw, Poland)

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In July 2021, the FDA issued Ardelyx a Complete Response Letter in which it stated that the molecules effect size was small and of unclear clinical significance. Then, in November 2022, an FDA advisory committee voted 9-4 that Xphozahs benefits outweighed its risks

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