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Vomiting is possible but a rare occurrence

SAM is known as the universal methyl donor as it serves to provide a methyl group for numerous methylation reactions, including those involving DNA, RNA, histones, proteins, membrane phospholipids, the synthesis of creatine, and the synthesis and metabolism of neurotransmitters

[DOI] [PubMed] [Google Scholar] 534

However, activation of IGF-IR may confer resistance to EZH2 inhibitors in diffuse large B cell lymphoma [143]

Therefore, we investigated the possibility that PDH-generated HNO may modify enzyme function in other environments