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doi: 10.1128/JVI.00603-16

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Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat

This may be due to its antioxidant activity, as well as its ability to regulate several proteins, which are involved in the cell cycle, such as NF- B, STAT3, MAPK, PI3K and a host of others

Ex vivo studies using aged kidney slices show FOXO4-DRI induces apoptosis in senescent cells within 3 days, demonstrating direct renal tissue penetration and efficacy