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In addition, there is a higher intensity of CD38 expression (measured by flow cytometry) in the more aggressive multi-hit variants, which allows further differentiation of the diseases and the use of CD38 as a biomarker for early diagnosis [14]

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Otherwise, serum concentrations of vitamin B12 were found in a lower level in NAFLD cases compared with those of the controls in 75 Turks (13), and decreased vitamin B12 concentrations were significantly associated with an increased fibrosis grade, as well as non-alcoholic steatohepatitis in 83 cases in Israel (45)

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Medicines used in PTC may cause serious side effects, including blood clots, stroke, and endometrial cancer in women taking SERMs (Hackney, 2018)

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