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Hepatic Metabolism and Mechanism(s) of Toxicity Following therapeutic administration of APAP, approximately 25% of dose is undergoes first pass metabolism, with the liver playing a primary role (37)
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10.1016/j.pathophys.2004.10.001 [DOI] [PubMed] [Google Scholar] Beaulieu J
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Once the estimated tumor volume stabilized at or above 50 mm, LOS was administered via drinking water at a concentration of 0.6 g/l for 6 weeks, or withheld in control groups, following the previously described protocol [26, 27]
