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Over time, the metabolic consequences of insulin deficiency such as glucotoxicity (and potentially other phenomena such as lipotoxicity) cause further beta cell injury and dysfunction, leading to a vicious cycle that promotes yet more dysfunction and loss of beta cells (Figure 1)

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At the end of this time, a statistically significantly higher proportion of dogs treated with GLME had shown improvement in their clinical condition (66.7% with GLME compared with 40.5% taking placebo

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Statistical Processing We used SPSS 20.0 statistical software for the data statistics