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However, existing studies primarily focus on short-term intervention effects at the cellular and animal levels, with a notable absence of comprehensive long-term behavioral assessments and safety evaluations

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Topical calcineurin inhibitors such as pimecrolimus cream or tacrolimus ointment may be used instead of topical steroids

Resveratrol, curcumin, melatonin, PQQ and vitamin D will also all inhibit TNF-alpha

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Their availability and procurement methods are also distinct