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Preventing necroptosis by scavenging ROS production alleviates heat stress-induced intestinal injury

10.2174/1386207324666210804122539 73 OrtizL

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H 2 O 2 reacts with ferrous iron (Fe 2+ ) in the Fenton reaction generating the highly toxic hydroxyl radical (OH) which can damage all cellular macromolecules (Imlay, 2003, 2008)

Oxidized proteins, for example, are preferred targets for proteasomal degradation, and damaged DNA is repaired by a number of excision-repair mechanisms
Toxicol Sci 123 , 193205, (2011)