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After treatment with 3-BrPA at different concentrations and for different durations, the effects of 3-BrPA were evaluated in terms of cell viability using a Cell Counting Kit-8 (CCK-8) assay and apoptosis using flow cytometry

2021;9 doi: 10.1136/bmjdrc-2021-002480

As described in Section 3.3.1.1, this relationship is mechanistically well supported in the context of tobacco smoke, where AHR-mediated induction of CYPs facilitates the metabolic activation of procarcinogens such as PAHs and nitrosamines

Yes, when administered by qualified medical professionals following a medical assessment

These typically occur when starting supplementation or with higher doses and often resolve as the body adjusts

Wang H, Yang C, Doherty JR, Roush WR, Cleveland JL, Bannister TD