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Originally developed by Metabolic Pharmaceuticals Ltd

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All TUEs for cannabis or other FDA-approved cannabinoid medications (e.g., Marinol, dronabinol) must meet the criteria set forth in the International Standard for TUEs in order to be approved

Liver detox function Hormonal balance Antioxidant activity (especially with methylated B12) Clearer skin and improved digestion This makes B12 a key part of many holistic and functional medicine detox programs

However, a larger follow-up pivotal trial, known as METAOD006 (or OPTIONS), enrolled a bigger cohort and failed to replicate statistically significant weight loss, leading the sponsoring company, Metabolic Pharmaceuticals, to halt the formal drug-development program in 2007