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Nevertheless, its narrow therapeutic window, characterized by rapid pharmacokinetic decline within 24 h post-administration, restricts its efficacy [11, 12]

Causes of increased oxidative stress are triggers of hemolytic crisis and include: Fava beans Drugs: antimalarial drugs (e.g., chloroquine, primaquine), sulfa drugs (e.g., trimethoprim-sulfamethoxazole), nitrofurantoin, isoniazid, dapsone, NSAIDs, ciprofloxacin, chloramphenicol Bacterial and viral infections (most common cause): Severe enzymatic deficiency can inhibit respiratory burst activity due to reduced NADPH production in phagocytes

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In something of the same spirit, Have a Ball (Prentice-Hall), by A

Another indication of the possible usage of Grx as a biomarker in specific tumours come from studies reporting Increased expression of Grx3 specifically in colon [220] and in bladder tumours [221] while Grx1 has been reported as a possible malignant marker in pancreatic duct carcinomas [222] and in the study by Zhao and collaborators, who sought non-invasive urinary markers for HCC, Grx1 expression decreased [219]