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The amylin pathway adds satiety more than it adds nausea which is the relevant data point for the reta+cagri layering question

Typically, treatment starts with the 2.5mg dose and is gradually increased to the 5mg dose.

Poplawska M, Dutta D, Jayaram M, Salifu M, Chong NS, Lim SH

Retrieved May 2, 2025, from (Content notes FDA approval 1997 and withdrawal 2008 for commercial reasons.) Askinazi, O

If you then maintain at 12mg weekly for 24 additional weeks (6 months), you need roughly 288mg more, or about 14-15 additional vials
