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The combination of repulsion and steric constraints is thought to remove the X-Y linker from near the active site and relieve auto-inhibition
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Briley-Saebo KC, et al
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Despite the fact that both groups had similar food intake and ambulatory exercise, COMBI therapy significantly reduced body weight increase induced by HFD, fat mass growth, and hepatic steatosis (Salic et al., 2019)
