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The initiation of RA by inflammation characterized by an aberrant Th-17-dominated immune response, neutrophil activation, antigen citrullination, and anti-cyclic citrullinated peptide (CCP) production is exacerbated by microbial dysbiosis, the presence of oral pathobionts (e.g., Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans ), and periodontitis has been described (165167)

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Iodine stimulates the myeloperoxidase activity of neutrophils, MF, increasing their bactericidal potential and inflammation, reduces the autophagy process

Slows early signs of ageing

Calada D, Vianello D, Giampieri E, Sala C, Castellani G, de Graaf A et al (2014) The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

Genetics can also cause high Hcy, with a common mutation in the MTHFR gene increasing the risk of heart disease and blood clots