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In HFD-fed male C57BL/6J mice, AX supplementation (25 mg/kg/day) during the final 5 weeks of a 15-week intervention significantly reduced body weight, total cholesterol, triglycerides, and LDL-cholesterol levels, while markedly upregulating uncoupling protein 1 (UCP1) expression in brown adipose tissue (BAT) and promoting browning of inguinal WAT, represented by increased UCP1 and PRDM16 levels [72]

Analytic tools that take into account the medical work up, such as RUCAM, should be used to further delineate the likelihood of causation

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