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The authors proposed that pulmonary endothelial ferroptosis triggers an inflammatory response through the HMGB1/TLR4/NLRP3 inflammasome signaling pathway in rats

For the shaved group, the drug was administered every other day for a total of 5 times, followed by observation of pigmentation on the backs of the mice

Borthakur G , Kantarjian H, Daley G, Talpaz M, O'Brien S, Garcia-Manero G, Giles F, Faderl S, Sugrue M, Cortes J
Expression levels of the genes were normalised against actin, which is a constitutively expressed housekeeping gene