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Symptoms of B12 deficiencyincluding fatigue, numbness in the hands or feet, difficulty concentrating, and mood changescan develop insidiously

The penumbra is where intervention matters most, because neurons in this zone can be saved if the right signals arrive in time

Considering the present work, we can recommend a dose of 1,000 g (1 mg) per day of oral cyanocobalamin for life in case of Biermers disease (Table 4) [23,26]

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There is a need to confirm the above-mentioned research results, as well as to thoroughly investigate the role of angiostatin in neurodegeneration, especially in preventing the development of these processes
