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Access this article Similar content being viewed by others Abbreviations GPx-1: Glutathione peroxidase-1 NQO1: NAD(P)H: quinone oxidoreductase 1 CAD: Coronary artery disease T2DM: Type-2 diabetes mellitus PKC: Protein kinase C CVD: Cardiovascular disease Nrf2/ ARE : NF-E2-related factor 2/antioxidant response element References Wild S, Roglic G, Green A, Sicree R, King H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030