ibuprofen effect on glutathione alters epoxide hydrolase activity and epoxy-oxylipin metabolites associated with different metabolic pathways in murine livers Benefits of Glutathione

Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II

Primary Structures and Classification of Glutathione Transferases 40 years ago scattered aminoacid sequence data were available for rodent and human GSTs

Regular ethanol consumption of greater than 250 mg/dL appears to be the threshold for enhancement of CYP 2E1 enzymatic activity

Lifestyle changes may include avoiding excessive sun exposure, smoking, and alcohol consumption

Most common: Acne / oily skin Libido changes Mood fluctuations (including irritability) Fluid retention Injection site pain, swelling, or bruising Elevated blood pressure Elevated hematocrit, hemoglobin, and PSA (lab monitoring required) Testicular shrinkage / atrophy Gynecomastia Night sweats Serious side effects may include: Polycythemia / elevated hematocrit (monitor CBC) Suppression of spermatogenesis / infertility while on treatment Elevated PSA Sleep apnea exacerbation DVT or PE (rare

While such inhibition causes modest or undetectable increases in H 2 O 2 contents, it triggers a marked perturbation of both the glutathione pool size and redox state (Smith et al., 1984