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Notably, this active targeting strategy leverages the EPR effect as its foundation

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Jain A, Lamark T, Sjttem E, Larsen KB, Awuh JA, vervatn A, McMahon M, Hayes JD, Johansen T

Interleukin-6 (IL-6) is the predominantly cytokine released by CAFs in response to the activation of the signal transducer and activator of transcription 3 (STAT3) via HIF-1

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