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Description
Using the APP/PS1 mouse model, a widely used platform for studying AD, 36 we treated KDS12008, KDS12017, and KDS12025 (3 mg/kg/day (mpk), 16 times, intraperitoneal injection) to assess their ability to alleviate AD-like symptoms

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Embracing proteostasis resilience as a central organizing principle provides both a conceptual lens and a translational strategy, guiding the development of next-generation interventions capable of restoring or strategically modulating equilibrium across diverse and complex disease states

BMC Genomics 13 , 424 (2012)
As mentioned above, fatty acid -oxidation is inhibited by APAP treatment, concomitant with compensatory increase of peroxisomal activity

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